| EPSRC Reference: |
GR/J76750/01 |
| Title: |
GEL-COATED PIEZOELECTRIC CRYSTAL SHEAR WAVE SENSORS FOR METABOLITE AND OTHER BLOOD COMPONENTS |
| Principal Investigator: |
Lewis, Professor TJ |
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| Department: |
Sch of Electronics |
| Organisation: |
Bangor University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 1994 |
Ends: |
30 August 1994 |
Value (£): |
82,120
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Summary on Grant Application Form |
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Supported by new theoretical understanding of their operation, the potential of piezoelectric quartz crystal resonant oscillators coated with gel-entrapped bioreactive molecules as sensors for medical application will be explored. Polyacrylyamide, polyvinyl alcohol, hydroxy ethylmethy- lacrylate and polyethylene oxide hydrogel coatings will be used with immobilised enzymes such as oxidases, lactate dehydrogenase and hexokinase to produce sensors for blood metabolites. Sensors for monitoring drugs such as salicylate and paracetamol in blood samples employing appropriate hydrogel-entrapped antibodies will also be studied. By denaturing the hydrogels to produce ionizable side groups and by varying pH, degree of crosslinking and buffer conditions the importance of sensor molecule-gel coupling in determining response will be investigated. In all cases the responses will be related to the theoretical viscoelastic model for the behaviour of quartz crystal sensors and strategies for optimum performance will be determined. The effects of biofouling by blood components and the response of sensors containing gell-entrapped cells subjected to environmental insult will be investigated.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bangor.ac.uk |