| EPSRC Reference: |
GR/H94160/01 |
| Title: |
DEVELOPMENT OF NOVEL COLLOIDS AND DRUG CARRIERS FOR TARGETING TO THE REGIONAL LYMPH NODES. |
| Principal Investigator: |
Davis, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Sch of Pharmaceutical Sciences |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 1993 |
Ends: |
31 March 1996 |
Value (£): |
172,929
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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Recently, we have been able to design an efficient targetting system for the delivery of diagnostic and therapeutic agents to the lymph nodes. For instance we have demonstrated that by careful modification of the surface hydrophobicity/hydrophilicity of small colloids, using polyoxy- propylene (POP)/polyoxyerhylene (POE) block copolymers, it is possible to deliver as much as 25% of the dose to the regional lymph nodes following interstitial administration. This is compared to the uptake of 5-8% of administered dose of other currently available colloids for lymphoscintigraphy and drug delivery. This project is designed to optimise the present system (in terms of particle size and surface characteristics) to a level that can be used for various visulisation modalities as well as drug delivery to the diseased lymph node. In order to have polymers that display optimal lymph node targeting activity and to follow structure-activity relationship we will synthesize POE-POP-POE and POE-polylactide block copolymers of defined characteristics and structure by step-wise addition of the constituent blocks. Attempts will be made to coat the surface of various drug carriers containing antitumour agents (to include oil-in-water emulsions, liposomes and poly(lactide-co-glycolide) microspheres) with such polymers and their ability to treat an experimentally induced lymphatic tumour model will be assessed.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |