| EPSRC Reference: |
GR/H54096/01 |
| Title: |
BIOPOLYMER IMPLANTS AND THEIR INTERACTIONS WITH WOUNDS |
| Principal Investigator: |
Ferguson, Professor MWJ |
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| Department: |
Cell and Structural Biology |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
LINK |
| Starts: |
16 March 1992 |
Ends: |
15 March 1995 |
Value (£): |
163,232
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Summary on Grant Application Form |
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1) To produce novel implants with controlled physical structures based on components such as fibronectin, collagen, hyaluronic acid and other active small molecules (chemotactic agents, angiogenic factors and new healing promoters). 2) Using in vitro cell culture models of fibroblast and epithelial cell growth, to investigate cellular and molecular responses to these implants. 3) Utilising data from 2) to optimise implant materials and, thereafter, continue work on in vitro models as well as specific animal models to identify and evaluate the effects of the composition and physical structure of the biopolymer implants (as guided tissue regeneration materials) on the processes of dermal wound healing through a programme of targeted applied research. These objectives will be achieved through the following critical steps: (a) establish a core group of expert scientists recruited from their specific fields within the three centres of academic excellence at Manchester, Bristol and Dundee; (b) at JJMGB, produce initial novel materials for testing; (c) set up models in vitro to study the interaction of the novel biopolymer implants with specific cell types; (d) use the data generated to optimise materials and inform the establishment of animal models of wound healing to study the effects of the materials in vitro; (e) using a battery of analytical methods, including unique monoclonal antibody probes, investigate the mechanisms of healing with special emphasis on the control of granulation and re-epithelialisation at the cellular and molecular level in the presence and absence of implants; (f) use data to produce prototype implants suitable for clinical trials. It is expected that, as a result of the proposed work, information will be accumulated that will shed further light on the complex critical steps involved in wound healing.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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