| EPSRC Reference: |
GR/A11571/01 |
| Title: |
AF:EXPLOITING PROTEIN-LIKE SELF-ASSEMBLY TO ENGINEER NOVEL NANOSTRUCTURED POLYMERIC MATERIALS & DEVICES |
| Principal Investigator: |
Aggeli, Dr A |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Centre for Molecular Nanoscience |
| Organisation: |
University of Leeds |
| Scheme: |
Advanced Fellowship (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2006 |
Value (£): |
226,485
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Structure |
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| Panel History: |
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Summary on Grant Application Form |
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I will design de de novo peptides using natural and non-natural side-chains. I willcharacterise the thermodynamics and kinetics of their self-assembly using a methodology developed frommy previous work. Comparative self-assembling studies will be carried using biological amyloid-formingpeptides. The data will be rationalised with mathematical models, in collaboration with theoriticians. I willcharacterise the gelling, liquid crystalline and nanoparticle-forming properties of these systems. On the basisof these results, I will establish a relationship between peptide primary structure, P-sheet self-assembly andmaterial properties. I will thus learn to control the type of polymer (tape, ribbon, fibril, fibre, transmembrane p-barrel, surface coating) and its properties, by peptide design. I will explore and develop the technologicalapplications of these soft solid-like materials in particular in the fields of tissue engineering, drug delivery,wound healing, dental care, biosensors, smart industrial fluids and separation of chiral molecules.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |