Details of Grant 

EPSRC Reference:	GR/A00084/01
Title:	SYNTHESIS AND BIO-ORGANIC CHEMISTRY OF NATURAL AND UNNATURAL HETEROCYCLIC COMPOUNDS
Principal Investigator:	Moody, Professor CJ
Other Investigators:
Researcher Co-Investigators:
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Department:	Chemistry
Organisation:	University of Exeter
Scheme:	Senior Fellowship (Pre-FEC)
Starts:	01 October 2000	Ends:	30 September 2005	Value (£):	348,664
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
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Summary on Grant Application Form
Heterocyclic molecules account for over half of all known chemical compounds. Many classes of natural products, as well as a large majority of commercially important drugs, agrochemicals, reprographic materials, dyes, etc., contain heterocyclic rings. Hence the synthesis and study of heterocyclic compounds is a subject of immense importance with direct relevance and benefit to UK industry. Heterocyclic chemistry was identified as a priority area in the 1998/1999 EPSRC Programme Landscapes document. Under this Fellowship it is proposed to pursue a broad research programme in heterocyclic chemistry with the emphasis on the development of new synthetic methods for the preparation of heterocyclic compounds, and their application in the synthesis of biologically active compounds, in particular cyclic peptides of the thiopeptide family of antibiotics and heterocyclic quinones as enzyme substrates. It is also proposed to investigate the interaction of heterocycles with biomolecules, and to study the mechanisms of action of cyclic peptide antibiotics, and enzymic reduction of heterocyclic quinones. Hence not only will synthetic organic chemistry be advanced under the Fellowship, but also it is proposed to use expertise in synthesis to address biological problems, to develop ideas at the interface between chemistry and the life sciences, and to enhance and develop our interdisciplinary collaborations.
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Organisation Website:	http://www.ex.ac.uk