| EPSRC Reference: |
EP/Z53108X/1 |
| Title: |
Instrument Development: A lab-scale soft X-ray microscope for biological systems |
| Principal Investigator: |
Frey, Professor JG |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Chemistry |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research TFS |
| Starts: |
11 March 2024 |
Ends: |
10 March 2028 |
Value (£): |
4,039,483
|
| EPSRC Research Topic Classifications: |
| Biophysics |
Instrumentation Eng. & Dev. |
|
| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
This instrument development application proposes the construction of a laboratory based, laser driven, water window x-ray microscope, capable of label free, nanometre spatial resolution, of biological samples with minimal sample damage.
The system makes use of the coherent nature of the x-ray radiation generated by high harmonic generation (HHG) from intense short pulse laser pulses. The coherent radiation is the basis of lensless imaging using algorithmic phase reconstruction (e.g. Coherent Diffraction Imaging and Ptychography).
The project builds on the current 29 nm imaging systems developed at Southampton and using recent advances in reliable fibre based laser technologies and in line with the Rosalind Franklin Institutes aims, will produce a system with more than an order of magnitude increase in both spatial resolution, data acquisition time, and enable the imaging of hydrated samples with minimal sample damage.
The system will be tested with several collaborations and in conjunction with the RFI and Harwell Research Complex imaging capabilities, and will be engineered to become a reliable facility to complement existing capabilities at the Central Laser Facility
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.soton.ac.uk |