EPSRC logo

Details of Grant 

EPSRC Reference: EP/V048031/1
Title: What do membranes really look like? New approaches to 3D multiplexed imaging of the cell surface
Principal Investigator: van de Linde, Dr S
Other Investigators:
Gould, Professor G
Researcher Co-Investigators:
Project Partners:
Department: Physics
Organisation: University of Strathclyde
Scheme: Standard Research - NR1
Starts: 01 July 2021 Ends: 30 June 2023 Value (£): 201,980
EPSRC Research Topic Classifications:
Biophysics
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
Proteins localised to the surface membranes of cells play key roles in normal and diseased cell biology and are the targets for the vast majority of existing pharmacological treatments. To understand these proteins on the molecular level, spatial mapping of their distribution on the surface of cells at nanometre resolution and in three dimensions (3D) is urgently required. We propose to use a combination of novel super-resolution microscopy and fluorescent labels to study the arrangement of transport proteins on the surface of fat cells. This work will thus act as a paradigm for a novel imaging approach of wide applicability and interest to academics and Big Pharma alike. Our proposal links the strategic EPSRC themes of Biophysics and Chemical Biology and will develop enabling platform technologies that will underpin many facets of life and medical sciences.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.strath.ac.uk