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Details of Grant 

EPSRC Reference: EP/T031301/1
Title: Matrix-assisted laser desorption/ionization mass spectrometry imaging for advanced chemical and materials analysis
Principal Investigator: Lockyer, Professor NP
Other Investigators:
Buckley, Dr M Flavell, Professor W Barran, Professor PE
McMahon, Dr A
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Manchester, The
Scheme: Standard Research
Starts: 01 August 2020 Ends: 30 September 2024 Value (£): 810,450
EPSRC Research Topic Classifications:
Analytical Science Catalysis & Applied Catalysis
Co-ordination Chemistry Design & Testing Technology
Surfaces & Interfaces
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
09 Mar 2020 EPSRC Strategic Equipment Interview Panel March 2020 - Panel 1 Announced
Summary on Grant Application Form
Mass spectrometry is an essential tool for molecular structural determination which underpins breakthroughs in Engineering, Physical Sciences and Life Sciences. In Matrix-Assisted Laser Desorption-Ionisation (MALDI) mass spectrometry, samples are analysed in the form of a solid, and surface chemical imaging is possible as part of a growing field in mass spectrometry imaging. Chemical imaging using mass spectrometry fill a critical gap in the materials characterisation toolbox, complementing physical imaging tools e.g. electron microscopy. Unravelling the chemistry of the surface of materials and devices is critical in understanding their interaction with their environment and improving their performance. The facility will provide exquisite detail on chemical structures, together with micrometre precision in spatial distribution.

The equipment will support research activities in Engineering & Physical Sciences and Life Sciences, encompassing both industrially relevant projects and blue-sky research. A strategic focus will be on Industrial Biotechnology and Advanced Materials, where analytical tools to characterise large molecules and complex systems are urgently needed in supporting the developing bioeconomy and novel healthcare technologies. Examples include enhanced production of new biopharmaceuticals or biodegradable polymers and wearable technology for medical diagnostics.

Our aim is to establish a multi-user analytical facility providing mass spectrometric chemical analysis and imaging. This will be managed, through proven mechanisms and support infrastructure, to maximise institutional, regional and national impact through collaborative research and major national academic-industrial networks.

Key Findings
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Potential use in non-academic contexts
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Date Materialised
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Project URL:  
Further Information:  
Organisation Website: http://www.man.ac.uk