EPSRC logo

Details of Grant 

EPSRC Reference: EP/T007397/1
Title: EPSRC-SFI: Glycoconjugate tools for sensing endoglycosidase activity: a diagnostic sugar probe for heparanase
Principal Investigator: Miller, Dr GJ
Other Investigators:
Watkinson, Professor M
Researcher Co-Investigators:
Project Partners:
Trinity College Dublin University of St Andrews
Department: Faculty of Natural Sciences
Organisation: Keele University
Scheme: Standard Research
Starts: 01 January 2020 Ends: 31 December 2022 Value (£): 368,582
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Chemical Biology
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
11 Sep 2019 EPSRC Physical Sciences - September 2019 Announced
Summary on Grant Application Form


This work will use exploratory scientific research to help further understand, and potentially disrupt, the way that cancer cells spread. This process is called angiogenesis and is central to all cancers. A critical part of angiogenesis is controlled by enzymes within cells that regulate the extracellular environment. More specifically, these enzymes act by breaking down biologically important carbohydrate molecules, called heparan sulfates, whose function is to switch on cellular signalling cascades, effectively initiating angiogenesis. We intend to design and synthesise a series of molecular carbohydrate tools that would be capable of detecting the activity of one of these key enzymes, called heparanase. Using our combined inter-disciplinary knowledge of synthetic carbohydrate chemistry and molecular sensing technology we will design and build molecular probes that can detect the activity of heparanase. The existence of this technology would then enable the future development of research programmes that use these tools to screen for and subsequently select potential inhibitors of heparanase, providing a route towards new therapeutic strategies against cancer.

Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.keele.ac.uk