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Details of Grant 

EPSRC Reference: EP/S027165/1
Title: Accessing pharmacophoric space via asymmetric protonation
Principal Investigator: Watson, Dr AJB
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Bristol Myers Squibb Company (Global)
Department: Chemistry
Organisation: University of St Andrews
Scheme: Standard Research
Starts: 01 April 2019 Ends: 31 March 2022 Value (£): 399,956
EPSRC Research Topic Classifications:
Asymmetric Chemistry Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Panel DatePanel NameOutcome
24 Jan 2019 EPSRC Physical Sciences - January 2019 Announced
Summary on Grant Application Form
Asymmetric catalysis has revolutionized the way molecules are made and are essential to the continued production of myriad products from small bioactive molecules to materials and from small scale to manufacture. A number of these processes have become privileged, with their impact demonstrated from tonne-scale application to the Nobel Prize. Increased mechanistic understanding of catalytic reactions underpins improvements of existing processes while driving development of new methods. By interrogating reactivity and selectivity in a newly described reaction, this proposal aims to bring new understanding to the underpinning catalytic processes while providing methods for the preparation of novel and synthetically powerful architectures.

Our preliminary studies using asymmetric protonation have recently been published and provide a solid foundation for the proposed work.

A series of additional supporting proof-of-concept experiments in support of this proposal have also given strong confidence in being able to deliver upon the objectives and aims of this proposal.

This proposal will comprehensively investigate this asymmetric protonation platform to allow predictability and the rational application of this chemistry as a method for the generation of scaffolds tailored towards application in Medicinal Chemistry, with specific applications within Chemical Development in collaboration with our industrial project partner.

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Organisation Website: http://www.st-and.ac.uk