EPSRC logo

Details of Grant 

EPSRC Reference: EP/S026045/1
Title: PET++: Improving Localisation, Diagnosis and Quantification in Clinical and Medical PET Imaging with Randomised Optimisation
Principal Investigator: Schoenlieb, Professor C
Other Investigators:
Gurnell, Dr M Mendichovszky, Dr I Ehrhardt, Dr MJ
Aigbirhio, Professor FI
Researcher Co-Investigators:
Project Partners:
GE Healthcare UCL
Department: Applied Maths and Theoretical Physics
Organisation: University of Cambridge
Scheme: Standard Research
Starts: 01 September 2019 Ends: 31 August 2022 Value (£): 821,421
EPSRC Research Topic Classifications:
Medical Imaging Statistics & Appl. Probability
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
05 Feb 2019 Healthcare Impact Partnership February 2019 Announced
Summary on Grant Application Form
Positron Emission Tomography (PET) is a pillar of modern diagnostic imaging, allowing non-invasive, sensitive and specific detection of functional changes in several disease types. In endocrinology, the precise localisation of small functioning tumours of the pituitary or adrenal glands is crucial for planning curative surgery or radiotherapy. While PET imaging shows good promise for this task, initial studies suggest significant room for improvement, with improved PET imaging and subsequent more accurate localisation opening up the possibility for more adapted therapies. In dementia, the accurate quantification of PET images is key for the early detection of disease. Improved PET imaging may allow for earlier detection of dementia while asymptomatic and increased sensitivity to assess and monitor treatment once appropriate drugs have been found.

In this project mathematicians team up with researchers and clinicians from Addenbrooke's Hospital Cambridge, Dementias Platform UK (DPUK), GE Healthcare and University College London (UCL) for improved diagnosis and localization for tumours in endocrinology and earlier diagnosis of dementia with improved PET imaging. In particular, we investigate modern PET reconstruction approaches based on advanced mathematical methods to increase the PET image resolution and contrast, while keeping computational complexity low, thereby directly benefiting clinical workflow.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.cam.ac.uk