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Details of Grant 

EPSRC Reference: EP/S019138/1
Title: In-situ NMR-based methodology for screening and optimisation of heterogenised organocatalytic systems
Principal Investigator: D'Agostino, Dr C
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Johnson Matthey
Department: Chem Eng and Analytical Science
Organisation: University of Manchester, The
Scheme: New Investigator Award
Starts: 01 June 2019 Ends: 30 November 2020 Value (£): 187,839
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals Energy
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Panel DatePanel NameOutcome
05 Dec 2018 EPSRC Physical Sciences - December 2018 Announced
Summary on Grant Application Form
The goal of this proposal is to develop and validate an in-situ Nuclear Magnetic Resonance (NMR)-based screening and optimisation methodology for heterogenised organocatalytic systems, able to monitor and evaluate catalyst activity, transport and surface interactions at a pore-scale level in such functionalised materials. Batch reaction studies combined with in-situ 1H and 13C NMR spectroscopy, diffusion and relaxation techniques will give new and exclusive insights into these systems by providing quantitative data on intra-pore kinetics, diffusion and adsorption, which will be able to direct catalyst formulation and reaction design by evaluating the controlling interactions and mass transport phenomena of the various reactant/solvent/product species within the pores of the heterogenised catalytic system, hence aid selection of optimal reaction parameters such as choice of suitable solvents, solid supports, pore size and type of linker to immobilise the organocatalyst on support. The validation of this methodology in heterogenised organocatalysis will be a significant step forward towards effective screening and development of these materials, which can be expanded to other related technologies using functionalised porous materials.
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Organisation Website: http://www.man.ac.uk