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Details of Grant 

EPSRC Reference: EP/S015892/1
Title: One size fits all: The semi-synthesis of new undecaprenol analogues for the study of multiple undecaprenyl-processing enzymes
Principal Investigator: Cochrane, Dr S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Trinity College Dublin
Department: Sch of Chemistry and Chemical Eng
Organisation: Queen's University of Belfast
Scheme: New Investigator Award
Starts: 01 January 2019 Ends: 31 December 2020 Value (£): 215,788
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Chemical Biology
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
12 Sep 2018 EPSRC Physical Sciences - September 2018 Announced
Summary on Grant Application Form
Antibacterial resistance is a major threat to human health and there is a pertinent need for new antimicrobial targets. Bacteria produce several glycopolymers that are vital to their survival, including peptidoglycan, which is a key component of the bacterial cell wall required for structural integrity. The bacterial cell wall is targeted by many clinically used antibiotics, such as penicillin and vancomycin. Glycopolymer biosynthesis involves several key glycolipid intermediates, all of which are linked to the cell membrane by the molecule undecaprenol. The enzymes that process undecaprenol-linked biomolecules are hot antibiotic targets, as they are unique to bacteria. However, detailed studies on these enzymes and the high-throughput screening of possible inhibitors has been limited due to the lack of suitable probes to monitor their activity. An understanding of enzyme mechanism is a vital pre-requisite to the rationale design of inhibitors. This project aims to develop new labelled analogues of undecaprenol, which will be used to study several novel antibiotic targets and provide a method for the high-throughput screening of potential antibiotic candidates.
Key Findings
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Organisation Website: http://www.qub.ac.uk