EPSRC logo

Details of Grant 

EPSRC Reference: EP/N031849/1
Title: Droplet-based Microfluidic Platform for Intracellular Ion Channel Drug Discovery
Principal Investigator: Zagnoni, Dr M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
AstraZeneca UK Limited Smartox Biotechnology
Department: Electronic and Electrical Engineering
Organisation: University of Strathclyde
Scheme: Standard Research
Starts: 01 October 2016 Ends: 30 September 2019 Value (£): 298,108
EPSRC Research Topic Classifications:
Microsystems Synthetic biology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Healthcare
Related Grants:
EP/N031636/1
Panel History:
Panel DatePanel NameOutcome
13 Apr 2016 Engineering Prioritisation Panel Meeting 13 April 2016 Announced
Summary on Grant Application Form
Ion channels are proteins that are involved in the regulation of almost every cellular mechanism and they constitute the second largest class of pharmacological drug targets. A family of these channels are located in the inner compartments of a cell (i.e. they are intracellular) and they are typically excluded from industrial large-throughput automated screening (e.g. automated patch clamp technology) that probe ion channels only in the outer cell membrane. As such, implications arise that affect the hit discovery rate of new drugs for such proteins. This proposal aims to produce and test a new microsystem technology for drug screening of human intracellular ion channels. The system will comprise a medium-throughput microfluidic prototype relying entirely on synthetic cell membranes harbouring intracellular ion channels. Whilst developing this new technology, this study will investigate two proteins that are involved in cancer and neurodegeneration, namely CLIC1 (used for validation) and CLIC4, which currently has no known pharmacological identified drug. Drug screening will be done in collaboration with industrial partners AstraZeneca and Smartox.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.strath.ac.uk