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Details of Grant 

EPSRC Reference: EP/N00941X/1
Title: Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices
Principal Investigator: Wilcox, Professor RK
Other Investigators:
Ingham, Professor E
Researcher Co-Investigators:
Project Partners:
credentis AG DePuy International Limited (UK) HealthTech and Medicines KTN
Invibio Ltd IP Group Plc Leeds Teaching Hospitals NHS Trust
Medicines & Healthcare pdts Reg Acy MHRA Neotherix Ltd Newcastle University
NHS Blood and Transplant NHSBT Quantum Imaging ltd Relitect Ltd.
Simpleware Ltd Simulation Solutions Tissue Regenix PLC
UCL University of Bradford University of Cambridge
University of East Anglia University of Liverpool University of Manchester, The
University of Nottingham University of Sheffield University of York
Xiros Plc
Department: Mechanical Engineering
Organisation: University of Leeds
Scheme: Standard Research - NR1
Starts: 01 July 2015 Ends: 31 January 2023 Value (£): 3,524,405
EPSRC Research Topic Classifications:
Biomaterials Biomechanics & Rehabilitation
Med.Instrument.Device& Equip. Medical Imaging
Tissue Engineering
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Panel DatePanel NameOutcome
04 Jun 2015 IKC - MTIKC Phase 2 Announced
Summary on Grant Application Form

Regenerative devices (scaffolds, biomaterials and interventions) which can repair and regenerate tissues using the patients` own cells, can be translated into successful clinical products and deliver patient benefit at much lower cost and risk and in shorter timescales then other regenerative therapies such as culture expanded cell therapies or molecular (drug) therapies. It is estimated that the global market for regenerative devices will grow to £50bn by 2020 and this offers a real opportunity to grow a £1bn per year industry in the UK in this field.

The UK has genuine research strengths in the areas of biomaterials and tissue engineering, musculoskeletal mechanics (prioritised by EPSRC) and regenerative medicine. Regenerative medicine is one of the eight great technologies prioritised across the Research Councils. Research discoveries, new knowledge, outputs and outcomes are often not ready for uptake by industry to take forward through product development to the market and patient benefit. New technologies need to be advanced and de-risked. The clinical needs, potential products and markets need to be defined in order to make them attractive for investment, product development and clinical trials by industry.

In the Medical Technologies Innovation and Knowledge Centre (MTIKC) Phase 1, working with industry and clinical partners, we have developed a professional innovation team and a unique innovation and translation process, creating a multidisciplinary research and innovation ecosystem. We have successfully identified research outcomes and new knowledge and created, advanced and translated technology across the innovation valley of death, enabling successful investment (over £100m) by industry and the private sector in new product development. Some products have already progressed to clinical trials and commercialisation and are realising patient benefits. We have established a continuous innovation pipeline of over fifty proofs of concept technology projects.

Over the next five years in MTIKC Phase 2, we will address unmet clinical needs and market opportunities in wound repair, cardiovascular repair, musculoskeletal tissue repair, maxillofacial reconstruction, dental reconstruction and general surgery and diversify our research supply chain to over ten other Universities. We will support 150 collaborative projects with industry and initiate forty new industry inspired and academically led proof of concept projects, which are predicted to lead to a further £100m investment by the private sector in subsequent product development. This will enable a sustainable research and product development pipeline to be established in the UK which will support a £1bn / year industry in regenerative devices beyond 2020.

Key Findings
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Potential use in non-academic contexts
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Date Materialised
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Organisation Website: http://www.leeds.ac.uk