| EPSRC Reference: |
EP/M506849/1 |
| Title: |
Automation of 3D cell model assembly by additive printing |
| Principal Investigator: |
Wildman, Professor R |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Faculty of Engineering |
| Organisation: |
University of Nottingham |
| Scheme: |
Technology Programme |
| Starts: |
30 September 2014 |
Ends: |
29 December 2015 |
Value (£): |
107,459
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| EPSRC Research Topic Classifications: |
| Design & Testing Technology |
Tissue engineering |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
This project shall test the feasibility of automating the manufacture of advanced cell-based analysis platforms by additive
printing of platform components. The analytical platforms shall be 3D cell cultures which enhance the function of resident
cells. Additive printing shall deposit biocompatible materials consistently and efficiently in 3D architectures within multiwell
culture plates compatible with medium-throughput analysis. 3D-printed structures designed to mimic tissue architecture
shall be populated with stem cell-derived populations with tissue-specific functionality selected to match the printed
architecture; the feasibility of printing cells directly into these structures shall be studied. For demonstration purposes, the
potential of automated additive printing shall be evaluated using hepatocytes derived from iPS progenitor cells and
deposited in liver-relevant 3D patterns, with model functionality being compared against competing systems and animal
models based on drug-metabolising enzyme levels. The outcome shall be a pre-industrial demonstration of the potential to
apply additive printing in the assembly of 3D cell-based assays used in drug discovery and other industrial processes. This
demonstration will create a springboard for further research and development aimed at automation of advanced cell-based
model assembly to industrial quality standards.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |