| EPSRC Reference: |
EP/M01715X/1 |
| Title: |
Novel Methodology for predicting the Functional Effects of Genetic Variation |
| Principal Investigator: |
Campbell, Dr C |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Engineering Mathematics and Technology |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research |
| Starts: |
01 June 2015 |
Ends: |
31 May 2018 |
Value (£): |
271,072
|
| EPSRC Research Topic Classifications: |
| Fundamentals of Computing |
|
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
Rapid developments in next-generation sequencing technologies
has lead to a rapid increase in identified genetic variants,
which may be implicated in disease. Laboratory-based experiments
to investigate functional consequences of these genetic variants
is a costly and time-consuming process. The core application focus of the project
is to construct algorithmically-based methods for predicting
the functional consequence of genetic variants, a problem where we have already
achieved some state-of-the-art results in certain contexts. 50% of the project period will be
given over to the design of improved algorithms specific to this application.
The other 50% of the project period will be given over to achieving
state-of-the-art performance with these new methods, and existing methods,
in application to the stated goal of predicting which variants, insertions
and deletion events are associated with human disease. The pathways to impact
is briefly described in the Case and more fully detailed in the Pathways to Impact
statement.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.bris.ac.uk |