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Details of Grant 

EPSRC Reference: EP/M006301/1
Title: Novel Point-of-Care Diagnostic Techniques for Dementia
Principal Investigator: Ifeachor, Professor E
Other Investigators:
Awan, Dr S Carroll, Dr C Doneddu, Dr D
Pan, Professor G Guy, Professor OJ
Researcher Co-Investigators:
Project Partners:
Prognomics Ltd
Department: Sch of Computing, Electronics & Maths
Organisation: University of Plymouth
Scheme: Standard Research
Starts: 01 February 2015 Ends: 31 July 2018 Value (£): 988,105
EPSRC Research Topic Classifications:
Analytical Science Materials Synthesis & Growth
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
27 Aug 2014 SIDD Prioritisation Panel Announced
Summary on Grant Application Form


The aim of this proposal is to create a new way, using multiplex graphene-based biosensors, for the detection of biomarkers found in biological fluids (e.g. blood, CSF, urine and saliva)

in the early stages of dementia (with emphasis on Alzheimer's disease) and changes in levels with disease progression.

A generic, Point-of-Care (POC) biosensor technology, based on graphene transducers, has already been developed by one of the project partners and demonstrated for

the detection of several disease biomarkers. Unlike existing analytical approaches, the sensor is a rapid diagnostic platform, yielding real-time data and a conclusive test

result within minutes of the sample being taken. The idea is to combine this with novel electronic multiplex techniques and large area graphene to create a multiplexed

biosensor array technology to enable the detection of multiple biomarkers of dementia simultaneously with the potential to significantly increase throughput.

An objective of the project is to demonstrate a novel, low-cost, reliable, POC diagnostic platform, based on multiplex graphene biosensors, for early detection of

dementia and following its progression from biological fluid such as blood.

The development of a low cost, point-of-care biosensing technology that makes it possible to detect dementia, objectively, in the early stages and to

monitor disease progression, rapidly, from a simple blood test would revolutionise diagnosis of dementia and have a huge positive impact on the selection of

subjects for clinical trials for new drugs and for monitoring response to treatment.

Key Findings
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Potential use in non-academic contexts
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Impacts
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Summary
Date Materialised
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Project URL:  
Further Information:  
Organisation Website: http://www.plym.ac.uk