Details of Grant 

EPSRC Reference:	EP/M005976/1
Title:	Multi-modal retinal biomarkers for vascular dementia: developing enabling image analysis tools
Principal Investigator:	Trucco, Professor E
Other Investigators:	MacGillivray, Dr T Wardlaw, Professor J Doney, Dr AS Dhillon, Professor B McKenna, Professor SJ Deary, Professor IJ Doubal, Dr F
Researcher Co-Investigators:
Project Partners:
Department:	Computing
Organisation:	University of Dundee
Scheme:	Standard Research
Starts:	30 April 2015	Ends:	28 August 2018	Value (£):	922,996
EPSRC Research Topic Classifications:	Biomedical neuroscience Medical Imaging
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 27 Aug 2014 SIDD Prioritisation Panel Announced
Summary on Grant Application Form
Dementia is a devastating disease. It has catastrophic implications for affected individuals, their family, wider society, and heavy, increasing costs for the NHS. Detecting subjects at increased risk of developing dementia in the future, and detecting adverse risk at the earliest stages of dementia, may present opportunities to preserve brain function and delay disease progression. There is increasing recognition that degeneration of brain blood vessels plays a role in the development of dementia. It is therefore important to identify patients likely to present such degeneration as early as possible, as they may require special treatment and the disease progress can be delayed. There is also strong clinical evidence that the brain blood vessels are related to those in the retina, the part of the eye responsible for the first stage of human vision. The retina is checked routinely by high-street opticians, hence retinal images (fundus photography and optical coherence tomography, now both available on a single device) could provide an inexpensive, non-invasive procedure capable of capturing early signs of dementia or those at high risk of developing dementia. It would exploit widely available existing examinations and be deployable immediately. Hence the potential impact of a retinal test for dementia signs would be huge. The central question is whether the retina can provide (a) reliable biomarkers (signs) for future risk of dementia, and (b) sensitive biomarkers of disease progression of either cognitive decline or brain vessels degeneration. Our purpose is to develop enabling technologies based on image analysis to identify such biomarkers, using easily accessible retinal features (supporting an uninvasive, inexpensive, easily accessible and high-specificity test), and joint brain-retina features (a larger-scope investigation motivated by the affinity of small vessels of brain and retina). We shall validate the technologies in a pilot study in collaboration with the specialist units at the University Hospitals of Dundee and Edinburgh, including ophthalmology, brain imaging, and cognitive ageing and cognitive epidemiology. Our research is supported by the Alzheimer's Society.
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Organisation Website:	http://www.dundee.ac.uk