EPSRC logo

Details of Grant 

EPSRC Reference: EP/L024012/1
Title: OxCD3: Oxford Centre for Drug Delivery Devices
Principal Investigator: Coussios, Professor C
Other Investigators:
Carlisle, Dr R C Vallis, Professor K Moyle, Dr S
Rabbitts, Professor T Sibson, Professor NR Seymour, Professor L
Friend, Professor P Stride, Dr Eleanor Cleveland, Professor RO
Researcher Co-Investigators:
Project Partners:
Cell Therapy Karl Storz Lein Applied Diagnostics Ltd
MedImmune Limited (UK) OrganOx Ltd Oxford Instruments Ltd
Pfizer PsiOxus Therapeutics Verasonics Inc
Department: Engineering Science
Organisation: University of Oxford
Scheme: Programme Grants
Starts: 23 July 2014 Ends: 22 July 2020 Value (£): 6,384,336
EPSRC Research Topic Classifications:
Drug Formulation & Delivery Med.Instrument.Device& Equip.
Medical Imaging
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:
Panel DatePanel NameOutcome
23 Apr 2014 Programme Grant Interviews - 23 April 2014 (Physical Sciences & Engineering) Announced
Summary on Grant Application Form
The greatest challenge in oncological drug delivery is achieving successful penetration and distribution of the therapeutic agent throughout the tumour: billions of pounds have been spent to date in deploying biochemical approaches in an attempt to solve what is essentially an engineering problem, namely the transport of therapeutics from the blood stream to reach every cancer cell.

OxCD3 will seek to transform both clinical and industry practice in drug delivery by demonstrating the value and feasibility of engineering approaches, involving a combination of stimulus-responsive nanocarriers and medical devices already in clinical use, for improved tumour uptake and therapeutic outcome. The Programme Grant will enable the creation of a sustainable, world-unique multi-disciplinary environment for combinational engineering of biology, chemistry and medical devices to improve drug delivery under a single roof. It is also expected to create a unique training environment for the next generation of young scientists working on combination therapies and biomedical nanotechnology, by providing direct exposure to regulatory and manufacturing issues encountered when translating laboratory research into production and clinical practice.

A unique feature of the Centre is the capability to design both devices and drug delivery vehicles under a single roof. In the first 5 years, under EPSRC funding, up to 3 carefully selected "Device+Drug" exemplars will be manufactured to GMP, ready for Phase I clinical trials, to provide compelling evidence of feasibility to industrial partners and clinicians; in the next 5 years, a private-public partnership will be built to complete clinical trials of these exemplars using therapeutics of strategic significance to the pharmaceutical industry; beyond 10 years, full industrial sponsorship of the OXCD3 is anticipated, which will focus on addressing next-generation challenges in drug delivery (beyond cancer) in partnership with industry and clinicians. The transformative aim over 50 years is to position the UK as the world leader for multi-disciplinary drug delivery development, complementing its existing position as a drug discovery leader, from design to manufacture and clinical trials.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.ox.ac.uk