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Details of Grant 

EPSRC Reference: EP/L017059/1
Title: Manufacturing Green Nanoparticles for Efficient Cell Manufacture
Principal Investigator: Johnston, Dr K
Other Investigators:
Patwardhan, Professor SV
Researcher Co-Investigators:
Project Partners:
Asylum Research Enterprise Europe Network
Department: Chemical and Process Engineering
Organisation: University of Strathclyde
Scheme: Standard Research
Starts: 22 May 2014 Ends: 21 October 2017 Value (£): 153,808
EPSRC Research Topic Classifications:
Continuum Mechanics Manufacturing Machine & Plant
Materials Characterisation Tissue engineering
EPSRC Industrial Sector Classifications:
Related Grants:
EP/L01730X/1 EP/L015269/1 EP/L015404/1
Panel History:
Panel DatePanel NameOutcome
21 Nov 2013 Early Careers Forum 2013 Call Announced
Summary on Grant Application Form
Material-cell interface, which strongly depends on surface and materials properties, can augment cell growth and is extremely useful in enabling exquisite control of cellular manufacturing. We will address challenges related to the total efficiency of the cell production process starting with nature-inspired manufacture of bespoke green nanomaterials (GN), characterizing these nanoparticles, and evaluating how these materials affect the subsequent cell manufacture. As part of this call, we seek limited proof-of-concept funding 2 years.

In order to manufacture green nanomaterials for efficient cell manufacture, there are following challenges:

- Can we scale up green nanomaterial manufacture so as to be competitive?

- How can we control flow to control manufacturing?

- Can we showcase the application of green silicas for cell manufacture?

- What nanoscale properties make green silicas superior?

We will address these challenges from a unique perspective by collaborating across non-traditional disciplines involving nanomaterials chemistry, fluid dynamics, cell manufacturing and nanotechnology, and combining expertise from two EPSRC Centres for Innovative Manufacturing and two EPSRC Manufacturing Fellows.

We have shown that GN, which provide an environmentally friendly approach, are scalable and have promising biomedical applications, while establishing the importance of mixing in nanomaterials scale-up operations. We have also identified strategies to efficient and automated cell manufacturing and developed nano-probes to extensively investigate surfaces and interfaces at the nanoscale. In this project, we aim to build on this success and go significantly beyond to address a number of key challenges to deliver large scale manufacturing of green nanomaterials suitable for cellular manufacture.

Key Findings
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Potential use in non-academic contexts
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Date Materialised
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Project URL:  
Further Information:  
Organisation Website: http://www.strath.ac.uk