| EPSRC Reference: |
EP/K034936/1 |
| Title: |
Plasmon-Enhanced Chiroptical Biosensors |
| Principal Investigator: |
Kadodwala, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research - NR1 |
| Starts: |
01 November 2013 |
Ends: |
31 December 2016 |
Value (£): |
779,670
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Biology |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
Polarimetry has been used for over two hundred years to detect and characterise inherently chiral biomolecules and
biomaterials. In this proposal we will use a 21st century "re-boot" of polarimetry, which uses chiral evanescent
electromagnetic fields produced by chiral plasmonic nanostructures instead of circularly polarised light, to achieve (sub)
picogram detection / characterisation of an analyte. We will develop biosensors that use plasmon-enhanced polarimetry,
superpolarimetry, to both transduce binding events and provide structural information on the bound analyte. These sensors
will provide label-free detection of analytes, and will be applied in an array-based format to the analysis of complex biofluids
while providing fundamental information on nanoscale chiroptical phenomena.
The vision at the heart of our research is the creation of a new sensor platform based on plasmon-enhanced chiroptical
effects. In addition to this goal, we expect that we will obtain fundamental advances in the understanding of chiroptical
behavior. In the course of our research we will develop new high-throughput methods to fabricate sensors, opening up
potential real-world applications of superpolarimetry. Taken together, our expectation is that the proposed research will
provide the foundational research required to bridge the gap between fundamental discovery and a widely useable sensor
platform.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |