EPSRC logo

Details of Grant 

EPSRC Reference: EP/K02566X/1
Title: Model driven design of dense phase wet granulation processes
Principal Investigator: Salman, Professor A
Other Investigators:
Hounslow, Professor MJ
Researcher Co-Investigators:
Project Partners:
Department: Chemical & Biological Engineering
Organisation: University of Sheffield
Scheme: Standard Research
Starts: 01 July 2013 Ends: 31 August 2014 Value (£): 249,670
EPSRC Research Topic Classifications:
Particle Technology
EPSRC Industrial Sector Classifications:
Food and Drink Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Panel DatePanel NameOutcome
24 Jan 2013 Engineering Prioritisation Meeting - 24/25 January 2013 Announced
Summary on Grant Application Form
Wet granulation is the process of using a liquid binder to form well structured and well behaved granules from difficult to handle fine powders. Granulation allows the development of structured particulate products with defined attributes (flowability, strength, dissolution profile, etc) from a fine powder feed. The granulation process is a key step in the production of a wide range of products important to the UK manufacturing industries including pharmaceuticals (GSK, Astra Zeneca), food and consumer products (Nestle, Procter and Gamble, Unilever), agricultural and specialty chemicals (Syngenta). It is often the most problematic step and can cause problems in product quality, time to market, and increased cost through unnecessarily high recycle.

Despite its industrial importance, approaches to the design and scaling of granulation processes are still very empirical in practice. Transfer of knowledge to new formulations, or to new equipment designs is difficult at best. The goal of this project is to develop a compartment based modeling framework for design and scaling dense phase wet granulation processes. We will develop and validate coupled discrete element (DEM)/population balance (PB) models to predict the evolution of granule property distributions for dense phase wet granulators. The specific project objectives are to:

1. Develop compartment based multiscale design models for dense phase wet granulation processes;

2. Validate these models using laboratory scale batch high shear wet granulators; and

3. Develop gSOLIDS modules for batch and continuous wet granulators and use these to develop and implement educational case studies.

The project will develop a new collaboration between Sheffield University and Purdue University (USA) through the visiting scientist, Professor Jim Litster from Purdue. A key outcome of the project will be the development of new tools to support the UK manufacturing industries in efficient manufacture of structured particulate products.

Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.shef.ac.uk