| EPSRC Reference: |
EP/K000888/1 |
| Title: |
INTERNATIONAL COLLABORATION IN CHEMISTRY: THE DEVELOPMENT OF CHEMICAL PROBES FOR HOPANOID FUNCTION |
| Principal Investigator: |
Conway, Professor SJ |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research |
| Starts: |
01 February 2013 |
Ends: |
31 January 2016 |
Value (£): |
294,117
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We are interested in studying a set of chemicals found in bacteria called hopanoids. These chemicals were thought to be 'molecular fossils' that provided information on the evolution of how bacteria processed chemicals and obtained energy. However, recent work has shown that the function of hopanoids is more complex than originally thought. Indeed, it seems likely that hopanoids still play an important role in recent bacteria. In order to understand better the function of hopanoids we are planning to make new and unnatural hopanoid derivatives that have additional functions that will assist these studies. We plan to make fluorescent ('glow in the dark') hopanoids that will allow us to study where they are found in cells. We also plan to make molecular 'fishing rods', using hopanoids as the 'bait', to determine what other molecules, especially proteins, that hopanoids interact with in cells. These chemical 'probes' will allow us to understand how the hopanoids exert their effects within cells and may potentially identify new targets for harming bacteria, which will be interesting for the development of antibiotics.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |