| EPSRC Reference: |
EP/J008095/2 |
| Title: |
Modelling composition-solubility relationships in bio-active phosphate glasses |
| Principal Investigator: |
De Leeuw, Professor NH |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research |
| Starts: |
01 January 2015 |
Ends: |
30 September 2015 |
Value (£): |
92,435
|
| EPSRC Research Topic Classifications: |
| Biomaterials |
Materials Characterisation |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The manufacture of biocompatible materials for tissue replacement is a central theme in the fields of biomedicine and tissue engineering research. Natural sources of bone graft material are compromised by availability and cost, both from the individual patient as autograft and from other donors as allograft. "Third generation" bioactive implant materials, which play an active role in tissue regeneration and degrade after the tissue has healed, have been remarkably successful in many clinical applications, especially in dental and orthopaedic fields. Among the third-generation biomedical materials, phosphate-based bio-active glasses (PBGs) are becoming increasingly popular owing to their unique properties: (i) their composition is chemically related to the surrounding tissue; (ii) they dissolve completely in aqueous media; (iii) their dissolution rate can be controlled by changing the composition of the phosphate-sodium-calcium glass. The solubility of the PBGs, which is arguably their most important property to be exploited in biomedical applications, can thus be tailored to suit the end application. As the solubility of a glass is linked to its atomic-level structure, insight into the P2O5 network structure at the molecular level; the effect of varying concentrations of calcium and sodium and other cations on the network; and the dominant surface and dissolution processes, are of fundamental interest to the design of phosphate glass compositions for applications in tissue engineering. However, a common problem in the investigation of these materials, generally related to their amorphous nature, is the lack of detailed information on the microscopic structure of the glasses and how this structure is affected by the different ions making up the glass composition. This research proposal therefore aims to develop robust models to provide quantitative insight at the atomic level into the structures, physico-chemical properties and solubilities of a range of phosphate-based bioglasses as a function of their composition.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.cf.ac.uk |