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Details of Grant 

EPSRC Reference: EP/I035579/1
Title: Chemical and biological approaches to sequence controlled polymers
Principal Investigator: O'Reilly, Professor RK
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Northwestern University
Department: Chemistry
Organisation: University of Warwick
Scheme: Standard Research
Starts: 01 December 2011 Ends: 31 May 2015 Value (£): 165,159
EPSRC Research Topic Classifications:
Materials Characterisation Materials Synthesis & Growth
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
Sequence controlled polymers (SCPs), linear macromolecules whose chemical and physical properties can be programmed with atomic-scale resolution, promise technological breakthroughs in novel materials, nanotechnology, and medicine. This technological promise provides ample motivation for development efforts towards their synthesis. However, at this time we are only able to synthesize limited kinds of SCPs, and our methods lack efficiency and they do not approach the accuracy, reproducibility, and control found in Nature. To address this challenge, this proposal describes the development of chemical (ring open polymerization) and biological (evolution of the translation apparatus) methods for the cost-effective and high yielding synthesis of sequence-defined vinyl polypeptides. Vinyl amino acids will be synthesized and incorporated into natural polymers, endowing biopolymers with new chemical functionality and serving as a model for synthetic of more complex template-directed SCPs.
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Further Information:  
Organisation Website: http://www.warwick.ac.uk