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Details of Grant 

EPSRC Reference: EP/I017887/1
Title: Next Generation Analytical Tools: Application to Protein Oxidations that affect Human Health and Wellbeing
Principal Investigator: Klug, Professor DR
Other Investigators:
Leatherbarrow, Professor RJ Cooper, Professor J Vilar Compte, Professor R
Spickett, Professor CM Pitt, Professor AR Morrice, Dr NA
Langridge-Smith, Dr P de Mello, Professor AJ Woscholski, Dr R
Neil, Professor MAA Ces, Professor O Willison, Professor KR
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: Imperial College London
Scheme: Standard Research
Starts: 01 September 2011 Ends: 29 February 2016 Value (£): 3,885,167
EPSRC Research Topic Classifications:
Cells Tissue Engineering
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Panel DatePanel NameOutcome
02 Sep 2010 Cross-Disciplinary Research Landscape Awards Announced
Summary on Grant Application Form
New and novel measurement tools and technologies enable modern biological and biomedical research to continue to move forward at a rapid rate. Detecting disease and evaluating the effects of drugs all rely on measurement technologies, and the limitations in our ability to measure things rapidly, accurately and cheaply is often the bottleneck in many research areas. Similarly, advances in industrial processes and clinical methods are often dependent on matching advances in measurement technology. In this programme two leading research centres from Glasgow University and Imperial College London join forces to develop new techniques and tools in order to improve existing approaches to detect and quantify the effects of protein oxidative damage in biological samples. Protein oxidative damage is one of the components of ageing and can cause a range of serious medical problems. As part of this project we will improve the ways in which biological samples are delivered into a range of analytical platforms such as mass spectroscopy and protein microarrays by employing novel innovative approaches such as acoustic sound waves, emulsion droplets and microfludics. Chemical tools and probes that seek out and detect damaged proteins will be constructed and subsequently incorporated into the technologies mentioned above. These technologies will be used to study the dynamics of protein damage in space and time. Another part of the programme develops high throughput analysis tools of various forms all of which use minaturisation methods to allow for the analysis of as many proteins as possible, as rapidly as possible and with as much detail as possible. It is anticipated that this multidisciplinary programme will create the necessary analytical platforms to overcome a technological gap that is holding back biological and medical discoveries in this research area that is vital for fostering our understanding of human health and ageing. It also has the potential to facilitate medical interventions to alleviate the symptoms of ageing and age-related illness. Given the importance of these issues for the general population, not just of the UK but worldwide, the impact of this programme will be significant and sustained for several years in terms of academic output as well as industrial wealth generation. In particular, novel drug targets and indeed drugs, as well as improved diagnostic techniques to monitor and assess human health and ageing are possible outcomes in the near future. Given the importance of oxidative damage in crop production it is likely that our programme will also produce tools that benefit the agrochemical industry, making this proposal a truly discipline crossing venture with respect to the sciences involved and the impact generated.
Key Findings
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Potential use in non-academic contexts
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Date Materialised
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Organisation Website: http://www.imperial.ac.uk