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Details of Grant 

EPSRC Reference: EP/I003398/1
Title: CH--O Hydrogen-Bonds as Structural Elements for Synthesis and Catalysis
Principal Investigator: Smith, Professor MD
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Oxford Chemistry
Organisation: University of Oxford
Scheme: Standard Research
Starts: 28 April 2011 Ends: 27 April 2014 Value (£): 364,062
EPSRC Research Topic Classifications:
Chemical Structure Protein folding / misfolding
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
30 Sep 2010 NSF/EPSRC Chemistry Proposals 2009 Announced
Summary on Grant Application Form
Nature has evolved large and complex molecules - proteins - which are comprised of simple building blocks that fold into specific three-dimensional shapes. These folded molecules are important for mediating many physiological chemical reactions. We are interested in examining the weak interactions that hold these molecules in their precise three-dimensional shape, and attempting to replicate them in simple synthetic systems. This involves the design and synthesis of molecules designed to fold into specific shapes, and simulation of their properties using high-level quantum calculation. The insight provided by these calculations will allow us to understand the forces that shape the properties of these small, designed molecules, and will also permit us to potentially emulate the exquisite specificity and reactivity exhibited by natural systems. We hope that this understanding will allow us to develop small, functional molecules that emulate some of the desirable properties of proteins.
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Organisation Website: http://www.ox.ac.uk