| EPSRC Reference: |
EP/H048871/1 |
| Title: |
Detecting pathological pathways of complex diseases |
| Principal Investigator: |
Emmert-Streib, Dr F |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Medicine, Dentistry & Biomed Sci |
| Organisation: |
Queen's University of Belfast |
| Scheme: |
First Grant - Revised 2009 |
| Starts: |
01 March 2011 |
Ends: |
30 June 2012 |
Value (£): |
101,130
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| EPSRC Research Topic Classifications: |
| Medical science & disease |
Statistics & Appl. Probability |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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13 Apr 2010
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Materials, Mechanical & Medical Engineering Panel
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Announced
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Summary on Grant Application Form |
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The aim of the proposed project is to develop a multivariate statistical method for the analysis of microarray data from complex diseases in order to detect pathological pathways. The proposed method will extent two preceding methods by improving them in several important ways. In brief, the most significant improvement is that the proposed method will allow a confirmatory as well as an explanatory analysis of the data. This is facilitated by the use of pseudo-pathways the test statistic will be based on which represent more than mere associations among genes. For this reason these pseudo-pathways contain information exploitable by an explanatory analysis that may enhance an biological understanding of the data beyond the results provided by hypotheses tests alone. This combination ensures an efficient data analysis to obtain the maximum amount of information usable for a functional interpretation of pathological pathways of complex diseases like cancer.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.qub.ac.uk |