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Details of Grant 

EPSRC Reference: EP/H008853/1
Title: Processing Nanoparticles in Suspension of High Solid Concentration: On-line Characterisation and Process Modelling
Principal Investigator: Wang, Professor X
Other Investigators:
Researcher Co-Investigators:
Project Partners:
3M FUJIFILM UK Ltd Syngenta
Department: Inst of Particle Science & Engineering
Organisation: University of Leeds
Scheme: Standard Research
Starts: 01 September 2010 Ends: 31 August 2014 Value (£): 331,584
EPSRC Research Topic Classifications:
Design of Process systems Particle Technology
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Panel DatePanel NameOutcome
09 Sep 2009 Process Environment and Sustainability (PES) Announced
Summary on Grant Application Form
Manufacture of nanometre particulate form products in suspensions is becoming increasingly important to the pharmaceutical, speciality chemical, and functional material industries. For instance, nano-processing is now used as an effective drug-delivery method for solid form hydrophobic pharmaceuticals due to the dramatically increased drug solubility and bioavailability at nano-scale. The biggest challenge to nano-processing under industrial conditions has been highlighted as the difficulty in achieving consistency in product quality as characterised by particle size distribution. The objective of this proposed research is to investigate on-line characterisation and process modelling techniques that can be applied under industrial operational conditions. The research on on-line sensing will focus on photon correlation spectroscopy and acoustic spectroscopy for real-time particle sizing. The work will tackle the key challenge posed by multiple scattering and particle-particle interactions, which are known to be the cause leading to incorrect measurement at high solid concentrations. High solid concentration is not only the economically viable range for commercial manufacture of nanoparticles (a much larger reactor would be required to process the same amount of particles in low concentration), but also technically essential for producing ultra-fine particles for many processes. The on-line real-time measurement will provide invaluable data to the development of process models using population balance equations. The focus will be on quantitatively deriving models for particle breakage and aggregation to be used in the population balance equations, as well as intelligent interpretation of the data to improve the qualitative understanding of the process. The process chosen for investigation is wet nano-milling, a very important operation for processing nanoparticles in the pharmaceutical, agrochemical and materials industries.
Key Findings
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Potential use in non-academic contexts
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Organisation Website: http://www.leeds.ac.uk