| EPSRC Reference: |
EP/H005854/1 |
| Title: |
DEVELOPING METAL CATION STABILISATION AS A GENERAL PARADIGM FOR O-C REARRANGEMENT PROCESSES |
| Principal Investigator: |
Harrity, Professor JPA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research |
| Starts: |
01 September 2010 |
Ends: |
28 February 2014 |
Value (£): |
126,126
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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06 May 2009
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Chemistry Prioritisation Panel May
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Announced
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Summary on Grant Application Form |
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The overall objective of this work is to develop new and efficient processes for the synthesis of organic molecules that bear useful functional groups. This is an important objective in organic chemistry because it provides the tools for the preparation of new molecular entities and consequently novel fine chemicals. The specific process proposed involves a skeletal rearrangement of a readily available substrate to a cyclic ketone - a common motif in bioactive compounds and natural products. A key element of this rearrangement is the presence of a cation stabilising group. Traditionally, this has been achieved by the incorporation of a proximal oxygen atom. The proposed work aims to use metal-hydrocarbon complexes to significantly expand the range of products available from this general strategy. We wish to study this process, establish its scope and limitations and explore the opportunity to generate new compounds with control of their three-dimensional shape.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |