Details of Grant 

EPSRC Reference:	EP/G056609/1
Title:	Delivering Hydroacylation as a General Reaction for Synthesis: A Combined Organic and Organometallic Approach
Principal Investigator:	Willis, Professor M
Other Investigators:	Weller, Professor A
Researcher Co-Investigators:
Project Partners:	East Carolina University
Department:	Oxford Chemistry
Organisation:	University of Oxford
Scheme:	Standard Research
Starts:	04 January 2010	Ends:	03 January 2013	Value (£):	646,013
EPSRC Research Topic Classifications:	Catalysis & Applied Catalysis Physical Organic Chemistry
EPSRC Industrial Sector Classifications:	Chemicals
Related Grants:
Panel History:	Panel Date Panel Name Outcome 10 Mar 2009 Chemistry Prioritisation Panel March Announced
Summary on Grant Application Form
The hydroacylation of alkenes and alkynes is a fundamentally simple process involving the addition of an aldehyde across and alkene or an alkyne to generate a ketone-containing product. Although a number of metal catalysts are known to promote the reaction the majority of these systems are inefficient, require harsh reaction conditions and have limited substrate scope. The aim of this proposal is to develop new catalysts systems that will allow the process to deliver products in high yields, using stable, easy to handle complexes that operate under mild conditions, and that function for a wide range of organic substrates. To arrive at this point we propose a collaborative program of research involving both organic and inorganic chemists. We will design new classes of ligands and catalysts that allow stabilisation of the key reactive metal-centre while still allowing the reaction to proceed. Preliminary results from our laboratories have shown that such an approach is valid. Along with catalyst design we will study the mechanism of the process using a variety of characterisation methods, and will build up a detailed understanding of the individual steps of the reaction. This mechanistic information will then be fed into the catalysts design loop to deliver yet more effective catalysts. Applications of the proposed chemistry includes the efficient synthesis of ketone and enone systems, ring-closing reactions to generate cyclic ketones, and the potential application of the chemistry to the synthesis of new polymeric materials.
Key Findings
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Further Information:
Organisation Website:	http://www.ox.ac.uk