| EPSRC Reference: |
EP/G030952/1 |
| Title: |
Amyloid Peptide Conjugates: Visit to Argentina to Develop Collaboration |
| Principal Investigator: |
Hamley, Professor IW |
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| Department: |
Chemistry |
| Organisation: |
University of Reading |
| Scheme: |
Overseas Travel Grants (OTGS) |
| Starts: |
29 January 2009 |
Ends: |
28 January 2010 |
Value (£): |
15,281
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
| Materials Synthesis & Growth |
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Summary on Grant Application Form |
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We propose to initiate a collaborative programme to examine the effect of peptide/polymer conjugates on amyloid fibrillisation in vitro and in vivo. The conjugates are expected to bind to amyloid and to disrupt fibrillisation. Members of the Reading team will visit Instituto Leloir (Buenos Aires, Argentina) to perform cell viability/cytotoxicity experiments. The Instituto Leloir was founded by the Nobel laureate Luis Federico Leloir and is one of the premier institutions devoted to biochemistry in South America, indeed it has a leading international profile. Members of the Leloir team will visit Reading for x-ray, neutron and electron microscopy experiments. Diseases such as Alzheimer's and type II diabetes are of increasing importance to the aging population in the developed world. They result result from the formation of amyloid in which proteins and peptides form fibrils based on a beta-sheet structure in which the peptide backbone is orthogonal to the fibril axis (cross beta structure). We propose to initiate a collaborative programme to examine the effect of peptide/polymer conjugates on amyloid fibrillisation in vitro and in vivo. The conjugates are expected to bind to amyloid and to disrupt fibrillisation in a stimuli-responsive fashion. The human amyloid peptide, Abeta is implicated in Alzheimers.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.rdg.ac.uk |