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Details of Grant 

EPSRC Reference: EP/G02796X/1
Title: Microfluidic Electrolytic Cells for Routine Synthesis in the Pharmaceutical Industry
Principal Investigator: Brown, Professor RCD
Other Investigators:
Birkin, Dr PR Pletcher, Professor D
Researcher Co-Investigators:
Project Partners:
Pfizer Syrris Inc
Department: Sch of Chemistry
Organisation: University of Southampton
Scheme: Standard Research
Starts: 01 August 2009 Ends: 31 July 2012 Value (£): 380,794
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology Electrochemical Science & Eng.
Microsystems
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
23 Sep 2008 Flow Chemistry Announced
Summary on Grant Application Form
Electrolysis is a synthetic procedure that avoids the use of stoichiometric and toxic/hazardous reagents and is usually carried close to ambient conditions. In addition, there is an extensive literature showing that reactions of interest to the pharmaceutical industry can be carried out with good selectivity. Despite this, and the consequential opportunity to develop more environmentally acceptable synthetic methods, the use of electrolysis is rare because of the need for specialist equipment and know-how. This project brings together a manufacturer of microflow equipment, industrial and academic synthetic organic chemists and electrochemists with experience of both organic electrosynthesis and equipment design/development in order (a) to develop user friendly microflow electrolysis equipment suitable for integration with traditional microflow systems (b) to show that the equipment is well matched to the challenges found in the pharmaceutical industry by optimising several conversions including the selective oxidation of alcohols to carbonyl compounds, the amination of alcohols, and partial fluorination.
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Organisation Website: http://www.soton.ac.uk