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Details of Grant 

EPSRC Reference: EP/G027919/1
Title: In-flow Preparation and use of Diazo Compounds for Heterocycle Construction
Principal Investigator: Hayes, Professor CJ
Other Investigators:
Moody, Professor CJ
Researcher Co-Investigators:
Project Partners:
Pfizer
Department: Sch of Chemistry
Organisation: University of Nottingham
Scheme: Standard Research
Starts: 28 May 2009 Ends: 27 May 2012 Value (£): 253,824
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
23 Sep 2008 Flow Chemistry Announced
Summary on Grant Application Form
Heterocyclic compounds, ring structures in which one or more carbon atom is replaced by nitrogen, oxygen or sulfur are of vast importance. They account for well over half of all known organic compounds, and many classes of natural products, as well as a large majority of commercially important medicines, agrochemicals and reprographic materials, contain heterocyclic rings. Hence the synthesis and study of such compounds is a subject of immense significance, both in academia and industry. The commercial relevance of heterocyclic compounds is amply demonstrated by the list of best selling pharmaceuticals - for the year 2006, six of the top ten best sellers were nitrogen heterocycles with combined sales of $41 billion. This proposal, which has the full support of Pfizer, seeks support to develop efficient in-flow routes to heterocyclic compounds, based on the versatile chemistry of diazo compounds.
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Organisation Website: http://www.nottingham.ac.uk