| EPSRC Reference: |
EP/G006695/1 |
| Title: |
Enantioselective Synthesis and Applications of Cyclochiral Rotaxanes |
| Principal Investigator: |
Lee, Dr A |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Engineering and Physical Science |
| Organisation: |
Heriot-Watt University |
| Scheme: |
First Grant Scheme |
| Starts: |
16 September 2008 |
Ends: |
15 June 2012 |
Value (£): |
279,178
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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01 Jul 2008
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Chemistry Prioritisation Panel (Science)
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Announced
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Summary on Grant Application Form |
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Rotaxanes are uniquely shaped interlocked structures consisting of a dumbbell shaped molecule which is threaded through a macrocycle . The two components are interlocked because the ends of the dumbbell are large enough to prevent the macrocycle from slipping off. Rotaxanes have progressed from subjects of academic curiosity to intense research interest; in most part due to their considerable potential in nanotechnology. The unique topology of rotaxanes, however, has rarely been exploited for synthetic purposes. The focus of this proposal is to synthesise a special type of rotaxane, possessing an interesting and unique form of chirality called cyclochirality . To date, there are no efficient or selective methods of synthesising these cyclochiral rotaxanes. We will apply innovative strategies to address this challenging problem. Two novel approaches will be developed, one involving metal catalysis and the other involving metal-free organocatalysis . We will subsequently study the applications of these cyclochiral rotaxanes in synthetic chemistry. We believe that the proposed work will open the door towards novel investigations in this area.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hw.ac.uk |