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Details of Grant 

EPSRC Reference: EP/F01564X/1
Title: Copy of Development of methods for characterising and testing clinical High Intensity Focused Ultrasound (HIFU) systems
Principal Investigator: Coussios, Professor C
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Churchill Hospital EDAP Technomed SA Imasonic S.A.
St Mary's Hospital Therus Corporation
Department: Engineering Science
Organisation: University of Oxford
Scheme: Standard Research
Starts: 01 July 2008 Ends: 30 September 2011 Value (£): 118,065
EPSRC Research Topic Classifications:
Acoustics Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Panel DatePanel NameOutcome
19 Sep 2007 Healthcare Engineering Panel (ENG) Announced
Summary on Grant Application Form
The clinical application of high intensity focused ultrasound (HIFU) to the treatment of soft tissue cancers of, for example, the liver, kidney and prostate, is a young and rapidly expanding field. To date more than 30,000 patients have been treated world wide. Successful treatment is achieved when the temperature of the tumour is raised to levels at which instantaneous cell death occurs. The focused beam ensures that only the tissue being targeted is heated, whilst surrounding tissue remains unharmed. Safe and effective use of HIFU requires that validated methods for measurement and testing of clinical devices should be made available as soon as possible. These issues have not been addressed to date in any systematic fashion. Clinical HIFU systems are currently assessed on an ad hoc basis by individual clinical departments and manufacturers, using methods, many of which are unpublished. There is, therefore, an urgent need to produce standard registration and testing equipment and methodology that allows users to characterize clinical HIFU systems for the purposes of checking safety and reproducibility of a machine's output, comparing different devices or commissioning new systems. The programme of work proposed is a mixture of adaptation and extension of existing and emerging techniques to meet the requirements of this new medical technology, and the development of novel methods specifically for this application.The overall aim of this project is to improve the efficacy, safety and range of applicability of clinical HIFU treatments by:A. providing validated methods for: * ultrasonic field characterisation using pressure field mapping and acoustic power measurement techniques; * HIFU system performance testing and quality assurance using novel thermal and cavitation mapping methods * patient exposure monitoring by means of electrical impedance measurements and real time acoustic power measurement;B. establishing a world leading HIFU characterisation facility at the Institute of Cancer Research (ICR);C. disseminating the successful methods, protocols and equipment to a wider user base through: * scientific publication; * contribution to written National and International Standards; * commercial exploitation.
Key Findings
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Date Materialised
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Organisation Website: http://www.ox.ac.uk