EPSRC logo

Details of Grant 

EPSRC Reference: EP/E501184/1
Title: Follow On: Novel Libraries of Building Blocks for Combinatorial Drug Discovery
Principal Investigator: Shipman, Professor M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Warwick
Scheme: Follow on Fund
Starts: 27 September 2006 Ends: 26 July 2007 Value (£): 64,021
EPSRC Research Topic Classifications:
Asymmetric Chemistry Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals
Related Grants:
Panel History:  
Summary on Grant Application Form
Hydantoins and their derivatives have many pharmaceutical and agrochemical applications. We have invented a simple, one-step method to an important subclass of these compounds, namely 5,5-disubstituted hydantoins. Chemical libraries of this type are rather inaccessible and appear underrepresented in commercial compound collections. Hence, there is scope to produce and market them to these industries. To develop this business opportunity, we must first establish if highthroughput techniques can be applied so that many saleable compounds can be made quickly and cheaply. Herein, we will explore both parallel synthesis methods and microwave acceleration. This project will also investigate the conversion of hydantoins into other important building blocks such as a,a-disubstituted a-amino acids. We aim to establish a company to exploit this technology and the work funded herein will produce the vital results needed to secure seedcorn funding and establish a sustainable business.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.warwick.ac.uk