EPSRC logo

Details of Grant 

EPSRC Reference: EP/E062091/1
Title: Self-organization in Immune Response
Principal Investigator: Grimble, Professor MJ
Other Investigators:
Garside, Professor P Brewer, Professor J Oppo, Professor GL
Researcher Co-Investigators:
Project Partners:
Department: Electronic and Electrical Engineering
Organisation: University of Strathclyde
Scheme: Standard Research
Starts: 01 August 2007 Ends: 31 October 2008 Value (£): 106,290
EPSRC Research Topic Classifications:
Control Engineering Medical science & disease
Theoretical biology
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The in vivo visualization of dynamic processes in lymphoid tissues by two-photon microscopy opens up possibilities for a combination of modelling, testing and experimental approaches to understand the behaviour of the immune system. A key element to develop larger models of immune response is the understanding of the cell activation, proliferation and interaction mechanisms.The aim of the project is to develop a theoretical and algorithmic framework to model and simulate the behaviour of T-cells in different environments and conditions using multi/agent dynamic systems and self-organizing systems. The proposed framework will reduce the burden on the modeling and simulation of immune system. A major step forward will be achieved by drawing inspiration from behavioural science, control engineering, physical and mathematical modelling. The final multi-agent model represents a multi-discipline integration of research concepts and simultaneously a substantial improvement of the present state of the art that fails to identify the mechanisms responsible for T-cell activation and proliferation. The integration of the activities in three research units at Strathclyde guarantees the accuracy of the final model that will be tested against a variety of experimental data and put the applicants in a unique position for the achievement of the objectives not just in the UK but also at an international level.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.strath.ac.uk