Details of Grant 

EPSRC Reference:	EP/E039855/1
Title:	Spectrometric and Spectroscopic Molecular Pathology and Diagnosis
Principal Investigator:	Baker, Professor MJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:	Christie NHS Foundation Trust Harvard University Paterson Institute for Cancer Research Robert Koch Institute
Department:	Chem Eng and Analytical Science
Organisation:	University of Manchester, The
Scheme:	Postdoc Research Fellowship
Starts:	01 October 2007	Ends:	21 December 2009	Value (£):	242,020
EPSRC Research Topic Classifications:	Analytical Science Cells Medical science & disease
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 09 Feb 2007 LSI Postdoctoral Fellowships Sift Panel 2007 InvitedForInterview
Summary on Grant Application Form
This proposal seeks to discover a novel process for staging disease based upon the molecular characteristics of cancer stem cells. We propose to use physical techniques and inherent physical phenomena of the samples as the basis to investigate a new realm for molecular pathology and also to use these techniques as an aid to current pathology.The research is needed into the fundamental differences between the associated model cell lines to enable the elucidation of biochemical markers to aid histopathology. The techniques are very complimentary - SIMS and MIMS are mass spectral techniques and ATR-IR and Raman are spectroscopic. Utilising these techniques we will cover the full range of elemental (isotopic), molecular and macromolecular information. This will provide translational molecular markers which can be identified by more clinically routine methods e.g staining for chemicals elucidated by this study.
Key Findings
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Potential use in non-academic contexts
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Impacts
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Sectors submitted by the Researcher
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Project URL:
Further Information:
Organisation Website:	http://www.man.ac.uk