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Details of Grant 

EPSRC Reference: EP/E030092/1
Title: Achieving 1,4-Additions to 'Impossible' Substrates
Principal Investigator: Woodward, Professor S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Chirotech Technology Limited
Department: Sch of Chemistry
Organisation: University of Nottingham
Scheme: Standard Research
Starts: 02 April 2007 Ends: 01 April 2008 Value (£): 94,053
EPSRC Research Topic Classifications:
Asymmetric Chemistry Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
There are no examples of catalytic aymmetric 1,4-additions of Grignard reagents (RMgX) to unsaturated amides (Case 1) despite the high synthetic utility that this transformation would offer. Similarly, no catalytic addition of a diorganozinc species (ZnR2) to an unsaturated esters (Case 2) has ever been reported. In collaboration with DowPharma we have recently uncovered the first examples of these two transformations. We wish to carry out a highly focused proof of application study for these remarkable reactions.
Key Findings
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Summary
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Further Information:  
Organisation Website: http://www.nottingham.ac.uk