| EPSRC Reference: |
EP/E028241/1 |
| Title: |
The motion of red blood cells through capillary bifurcations |
| Principal Investigator: |
Blyth, Professor M |
| Other Investigators: |
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| Department: |
Mathematics |
| Organisation: |
University of East Anglia |
| Scheme: |
Standard Research |
| Starts: |
12 March 2007 |
Ends: |
11 July 2010 |
Value (£): |
64,132
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| EPSRC Research Topic Classifications: |
| Continuum Mechanics |
Medical science & disease |
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Summary on Grant Application Form |
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We will perform a study of the motion of an elastic capsule through a branching tube as a model of a red blood cell passing through a bifurcation in the human capillary system. We will start with a two-dimensional model of a single fluid-filled elastic capsule passing through a channel with aside-branch and use the boundary integral method (BIM) to study the passage and deformation of the cell under a variety of flow conditions. Next, we will develop a realistic three-dimensional modelof an axisymmetric red blood cell moving through a straight or curved bifurcating pipe, and incorporate a realistic description of the biomechanics of the red blood cell membrane. The BIM will again be used to compute the stresses and bending moments developing in the cell and the deformation of the membrane during transit through the bifurcation. The method will be extended to deal with multiple cells to yield predictions of the cell volume fraction in the daughter branches, to allow assessment of cellaggregation, and to provide predictions of the effective blood viscosity. The results will provide much needed deeper insight into the workings of the human microcirculation which will help combatdisease and will aid in the development of synthetic blood substitutes..
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |