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Details of Grant 

EPSRC Reference: EP/E021042/1
Title: Colloidal Cell Delivery Systems
Principal Investigator: Alexander, Professor C
Other Investigators:
Davies, Professor M Shakesheff, Professor K
Researcher Co-Investigators:
Project Partners:
Department: Sch of Pharmacy
Organisation: University of Nottingham
Scheme: Standard Research
Starts: 15 January 2007 Ends: 14 January 2010 Value (£): 186,268
EPSRC Research Topic Classifications:
Complex fluids & soft solids Drug Formulation & Delivery
Materials Synthesis & Growth Surfaces & Interfaces
Tissue Engineering
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Healthcare
Related Grants:
EP/E02078X/1
Panel History:  
Summary on Grant Application Form
As stem cell technologies advance towards clinical application there is an urgent need to enhance the methods of delivering these cells into the body. Current methods of simple injection of cell suspensions are crude because they waste cells, compromise viability and generate poor starting conditions for the regeneration of a tissue. In this collaborative project between the universities of Nottingham and Manchester we will establish an injectable material consisting of a colloid mixture of cells and particles that is injectable at room temperature and aggregates into a porous colloidal gel at body temperature. This material could form the basis for cell delivery in neurology, endocrinology, hepatology, orthopaedics and many other areas because the components are well understood and trusted materials with long track records of use in the body. A successful outcome for this project will prove the principle of cell delivery into skeletal muscle tissue using temperature-triggered assembly and establish the fundamental principles involved.
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Project URL:  
Further Information:  
Organisation Website: http://www.nottingham.ac.uk