EPSRC logo

Details of Grant 

EPSRC Reference: EP/E018203/1
Title: Bond Formation Studies By Charge Density Measurements and Solid State 17O NMR Spectrometry
Principal Investigator: Wallis, Professor JD
Other Investigators:
Smith, Professor ME
Researcher Co-Investigators:
Project Partners:
University of Southampton
Department: School of Science & Technology
Organisation: Nottingham Trent University
Scheme: Standard Research
Starts: 12 March 2007 Ends: 11 January 2011 Value (£): 332,399
EPSRC Research Topic Classifications:
Chemical Synthetic Methodology Physical Organic Chemistry
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:
Panel DatePanel NameOutcome
02 Jun 2006 Physical Organic Chemistry Sift Panel (Science) Deferred
Summary on Grant Application Form
This project concerns the formation of chemical bonds. The reactions chosen are addition reactions of electron-rich groups such as amines or those containing negatively charged oxygen atoms with electron-poor groups such as carbon-carbon double bonds which have electron attracting groups attached. Molecules will be prepared which have a pair of such groups held in close proximity. The degree of bond formation between them will be detected by measurements of the electron density between them, and by nuclear magnetic resonances (NMR) measurements on powdered crystalline samples - detecting either the nitrogen (as 15N) or oxygen (as 17O) atom of the electron-rich group. These measurements are at the cutting edge of both these techniques. The electron density distribution on a particular molecule is determined from very accurate X-ray diffraction measurements (XRD) on a small crystal, and this will contribute to the growing use of this technique internationally to examine weak bonding interactions. Of particular importance is to determine how the properties of the electron density distribution between the reacting groups changes as the distance between the groups decreases i.e. as the bond forms. Use of NMR measurements on powdered crystalline samples means that the solid state structure determined by X-ray diffraction, can be directly related to the position of the signal from N or O in the NMR experiment. The NMR measurements using 17O will be ground breaking, since this has only become feasible through recent developments of the technique, including double rotation of the sample in the magnetic field. Nevertheless, for the 17O measurements it will be necessary to prepare compounds which are enriched in the 17O isotope. Finally, and of particular importance, the choice of cation accompanying the oxygen anion will be varied to determine how this alters the reactivity of the oxygen anion, which will be monitored by structural (XRD) and NMR measurements building on earlier results. The reactivity of the oxygen would be expected to be decreased by cations which bind more tightly to it, and our measurements will provide an approach to quantify this.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.ntu.ac.uk