Details of Grant 

EPSRC Reference:	EP/E011217/1
Title:	Total synthesis of (+)-aspercyclide a and its analogues
Principal Investigator:	Spivey, Professor A
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	Imperial College London
Scheme:	Standard Research
Starts:	15 January 2007	Ends:	14 January 2010	Value (£):	299,995
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
Allergic disorders such as hay fever and asthma currently afflict approximately one quater of the population of Europe and the USA. Current therapies only alleviate symptoms, they do prevent the conditions. The research proposed here is geared towards the development of an efficient chemical preparation of a natural substance, (+)-aspercyclide A, that is known to inhibit a key protein-protein recognition event involved in all allergic pathways and which could represent a crucial lead for the development of new preventative treatments for allergic disorders. The chemistry that is proposed to be developed will also allow structural analogues of the natural substance to be readily prepared such that, following biological screening, more potent substances can be identified.
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Organisation Website:	http://www.imperial.ac.uk