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Details of Grant 

EPSRC Reference: EP/D502721/1
Title: Spectroscopic imaging of skin and its application to (trans)dermal delivery
Principal Investigator: Kazarian, Professor SG
Other Investigators:
Researcher Co-Investigators:
Dr KLA Chan
Project Partners:
Department: Department of Chemical Engineering
Organisation: Imperial College London
Scheme: Standard Research (Pre-FEC)
Starts: 15 February 2006 Ends: 14 November 2008 Value (£): 176,708
EPSRC Research Topic Classifications:
Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
EP/D502748/1 EP/D50273X/1
Panel History:  
Summary on Grant Application Form
We propose to develop applications of advanced spectroscopic methods (FTIR imaging and confocal Raman microscopy) for studying (trans)dermal delivery. These methods will be combined with the use of multivariate chemometrics for enhanced data analysis. The research is based on a unique opportunity of bringing 3 research groups together that can elucidate mechanisms of percutaneous absorption. The spectroscopic expertise will be combined with groups specializing in drug delivery and pharmaceutical analysis. The programme of work will explore applications of FTIR imaging in micro- and macro ATR imaging modes to skin samples in contact with formulations. Macro-ATR imaging will be applied for the first time to study in situ dynamic process of permeation of model formulations through the skin. A broader goal is to facilitate the use of FTIR imaging for skin research by revealing the underlying mechanisms of mass transport through the various strata of the skin. The combined application of FTIR imaging, confocal Raman spectroscopy and advanced chemometrics techniques to skin samples will provide a valuable database for the better design of medicines for skin treatment.
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Further Information:  
Organisation Website: http://www.imperial.ac.uk