Details of Grant

EPSRC Reference:

EP/D07410X/1

Title:

Enzyme Responsive Materials for Biology and Medicine

Principal Investigator:

Ulijn, Professor R

Other Investigators:

Researcher Co-Investigators:

Project Partners:

Department:

Materials

Organisation:

University of Manchester, The

Scheme:

Advanced Fellowship

Starts:

01 August 2006

Ends:

31 August 2008

Value (£):

649,958

EPSRC Research Topic Classifications:

Chemical Structure	Complex fluids & soft solids
Drug Formulation & Delivery

EPSRC Industrial Sector Classifications:

Healthcare

Pharmaceuticals and Biotechnology

Related Grants:

Panel History:

Panel Date	Panel Name	Outcome
20 Apr 2006	Materials Fellowships 2006 - Interview Panel	Deferred
31 Mar 2006	Materials Fellowships 2006 - Sift Panel	Deferred

Summary on Grant Application Form

This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.

Key Findings

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Potential use in non-academic contexts

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Impacts

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Summary
Date Materialised

Sectors submitted by the Researcher

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Project URL:

Further Information:

Organisation Website:

http://www.man.ac.uk