| EPSRC Reference: |
EP/D069521/1 |
| Title: |
Combined use of organo- and enzymic catalysis in three component couplings: Building blocks for bioactive molecule synthesis |
| Principal Investigator: |
Nelson, Professor AS |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research |
| Starts: |
01 November 2006 |
Ends: |
31 October 2009 |
Value (£): |
99,746
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The preparation of biological molecules, such as drugs and agrochemicals, generally involves many separate synthetic steps. At the end of each step, an intermediate is usually purified before functionalisation in the next step. To improve the efficiency of the construction of such molecules, the number of separate reactions and purifications would need to be reduced. This proposal will generate new methods which will allow more than one step to be performed in a single reaction vessel. This approach is broadly analogous to would involve the concatenation of several steps Nature: metabolic pathways involve the processing of reaction intermediate by compatible (enzyme) catalysts in a single reaction vessel (the cell). The products of the new methodology will be exploited in the synthesis of building blocks for preparation of biologically active molecules.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |