Details of Grant 

EPSRC Reference:	EP/D036593/1
Title:	Tribological Modelling of Biphasic Articular Cartilage and Cartilage Replacement Systems in Anatomical and Physiological Models
Principal Investigator:	Jin, Professor Z
Other Investigators:	Fisher, Professor J Ingham, Professor E
Researcher Co-Investigators:	Professor S Williams
Project Partners:
Department:	Mechanical Engineering
Organisation:	University of Leeds
Scheme:	Standard Research (Pre-FEC)
Starts:	05 June 2006	Ends:	04 December 2009	Value (£):	180,377
EPSRC Research Topic Classifications:	Biomaterials
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
Treatment of end stage arthritis currently involves major surgical intervention in the form of total joint replacement. However, due to the clinical limitation of these devices (generally less than 15 years), there are concerns about their use in increasing numbers of younger patients with arthritis of the major load bearing joints without a secondary operation. Consequently, there are emerging interests in earlier intervention approaches such as partial surface replacement and cartilage substitution, which attempt to retain some or all of the functional bearing surface of articular cartilage. The increasingly rigorous ethical and regulatory environment is demanding more extensive pre-clinical studies, as part of the translation of any new technology to the patient. However, there are currently no pre-clinical functional simulation models that can be used to assess the potential long-term clinical performance of these devices which articulate against articular cartilage. The aims of this project are to develop novel computational models for investigating the tribology (friction, wear and lubrication) of articular cartilage in order to understand the normal function as well as to provide guidance for developing early intervention cartilage substitution solutions in the hip joint. The computational model will particularly focus on the biphasic (fluid and solid phases) loading carrying capacity of articular cartilage and integrate contact mechanics, friction, lubrication and wear using an anatomical and physiological joint model. Both cartilage against cartilage and cartilage against a biomaterial such as metal (hemi-arthroplasty) will be modelled. The computational model will be validated using a porcine hip joint model before use on the human hip joint. The outcome of the proposed research will provide guidance for developing novel tissue substitution solutions in the future.
Key Findings
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Potential use in non-academic contexts
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Project URL:	http://imbe.leeds.ac.uk
Further Information:
Organisation Website:	http://www.leeds.ac.uk