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Details of Grant 

EPSRC Reference: EP/D03454X/1
Title: Ultrasonic manipulation and transport of DNA molecules in evanescent light fields
Principal Investigator: Hill, Professor M
Other Investigators:
Wilkinson, Professor JS Harris, Dr N Melvin, Dr T
Researcher Co-Investigators:
Project Partners:
Defence Science & Tech Lab DSTL Genetix Ltd Point Source Ltd
Department: Faculty of Engineering & the Environment
Organisation: University of Southampton
Scheme: Standard Research (Pre-FEC)
Starts: 13 August 2006 Ends: 12 January 2010 Value (£): 379,811
EPSRC Research Topic Classifications:
Chemical Biology Instrumentation Eng. & Dev.
Microsystems
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
Ultrasonic Standing Waves (USWs) can be used to manipulate particles within a fluid. Used within chambers of a half wavelength depth or less, the ultrasonic radiation forces can move the particles either to a central plane within the chamber or to a wall of the chamber. This project is a multidisciplinary investigation into the use of USWs in microfluidic biosensing applications. It involves the School of Engineering Sciences (SES), the Optoelectronics Research Centre (ORC) and the Microelectronics Research Centre in the Department of Electronics and Computer Science (ECS) at the University of Southampton. The work aims to integrate optical sensing and USW excitation using techniques and materials compatible with emerging microfluidic technology. It will also use the optical/USW techniques to study and quantify the behaviour of the USW chamber, particularly with regard to the ability of quarter wavelength chambers to move particles to the chamber wall. The project will apply these techniques to the detection of a number of DNA sequences in a mixture. It will also investigate the feasibility of using acoustic radiation forces to interrogate single DNA sequences with a high resolution.
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Project URL:  
Further Information:  
Organisation Website: http://www.soton.ac.uk